Research area · week to 3 Oct 2026

Gastrointestinal motility and disorders

Moving in Gut.

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In-person therapist-delivered hypnotherapy versus smartphone-based self-guided hypnotherapy in IBS: a multicentre three-armed randomised controlled trial.
Gut · 25 July 2026 · Journal Article
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Efficacy of gut-brain neuromodulators and brain-gut behaviour therapies for irritable bowel syndrome: systematic review and network meta-analysis.
Gut · 26 June 2026 · Journal Article
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Randomized Sham-Controlled Trial of Translumbosacral Neuromodulation Therapy for Fecal Incontinence.
Gastroenterology · 1 Oct 2026 · Randomized Controlled Trial
Translumbosacral neuromodulation therapy with 2400 and 3600 magnetic pulses significantly reduces fecal incontinence episodes compared to sham, with responder rates up to 81.1%.
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https://jclub.com.au/a/42105947
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Finding the Signal in the Noise: Can Fecal Microbiota Transplantation Deliver for Irritable Bowel Syndrome?
Gastroenterology · 1 Oct 2026 · Editorial
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Fusobacterium nucleatum enhances enterotoxigenic Bacteroides fragilis-mediated neuron loss and intestinal motility dysfunction.
Nature Microbiology · 1 Oct 2026 · Journal Article
Fusobacterium nucleatum amplifies Bacteroides fragilis-induced neuron loss and gut motility issues, with 2-hydroxybutyric acid worsening neurotoxicity in mice.
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Regional organization of nutrient absorption across the small intestine.
Nature reviews. Gastroenterology & hepatology · 1 Oct 2026 · Review
Molecular and functional organization of nutrient absorption varies regionally along the small intestine, with distinct gene expression profiles across axes.
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Barrier restoration as a therapeutic strategy for disorders of gut-brain interaction.
The lancet. Gastroenterology & hepatology · 1 Oct 2026 · Review
Restoring gut barrier function with targeted therapies could transform treatment of gut-brain interaction disorders, reducing symptoms in conditions like IBS and dyspepsia.
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Fecal Microbiota Transplantation for Symptom Improvement in Patients With Irritable Bowel Syndrome: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Gastroenterology · 1 Oct 2026 · Systematic Review
Fecal microbiota transplantation shows potential to improve irritable bowel syndrome symptoms, with significant effects observed in some analyses but overall very low certainty evidence.
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https://jclub.com.au/a/42162772
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Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753972
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Wall stiffening is a primary contributor to motility loss in Crohn's disease: an electromechanical modeling study
bioRxiv · 25 Sept 2026 · Preprint
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ESPEN 2026.
Nature reviews. Gastroenterology & hepatology · 23 Sept 2026 · Conference Proceedings
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Multi-kingdom gut microbiota analyses identify biomarkers of different types of pediatric short bowel syndrome.
mSystems · 22 Sept 2026 · Journal Article
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Deoxycholate induces proline provision from Escherichia coli to enhance Clostridioides difficile virulence.
The ISME Journal · 17 Sept 2026 · Journal Article
Deoxycholate promotes Clostridioides difficile virulence by stimulating Escherichia coli to produce proline, boosting infection severity by 50-fold in co-infection models.
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Faecalibacterium prausnitzii EXL01 Strain for the prevention of multiple-recurrent Clostridioides difficile Infection.
Gastroenterology · 17 Sept 2026 · Journal Article
A single Faecalibacterium prausnitzii EXL01 strain significantly reduces recurrent Clostridioides difficile infection in humans, with 83.3% remaining recurrence-free at 8 weeks.
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Clostridioides difficile rewires the infant gut.
Nature Reviews Microbiology · 16 Sept 2026 · Journal Article
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Notch signalling governs human enteric nervous system progenitor dynamics
bioRxiv · 10 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.01.722150
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Multinational prevalence and burden of paediatric disorders of gut-brain interaction: results of the Rome Foundation paediatric global study.
Gut · 7 Sept 2026 · Journal Article
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https://jclub.com.au/a/42613193
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Rome V global epidemiology and validation survey: prevalence of disorders of gut-brain interaction and comparison with the Rome IV global epidemiology study.
Gut · 7 Sept 2026 · Comparative Study
The global prevalence of disorders of gut-brain interaction remains consistent at around 41% using Rome V criteria, confirming high worldwide burden.
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Development and validation of a machine learning scoring system based on multi-dimensional metabolic signatures for invasive examination triage in intestinal diseases.
Frontiers in Genetics · 7 Sept 2026 · Journal Article
A machine learning scoring system using metabolic biomarkers achieves an AUC of 0.910 for IBD diagnosis, surpassing traditional fecal calprotectin tests.
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Presentation of the AGA William Beaumont Prize in Gastroenterology to Stuart Jon Spechler, MD, AGAF.
Gastroenterology · 3 Sept 2026 · Editorial
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Individualized Targeted Exclusion Diet Based on Confocal Laser Endomicroscopy Does Not Improve Irritable Bowel Syndrome Symptoms: A Randomized Controlled Crossover Trial.
Gastroenterology · 1 Sept 2026 · Journal Article
Targeted exclusion diets based on confocal laser endomicroscopy do not significantly improve irritable bowel syndrome symptoms, with response rates of 42% versus 36%.
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Dietary management of gastrointestinal disease: progress over the last decade and opportunities for the next.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Recommendations for the Evaluation and Management of Inflammatory Bowel Disease With Irritable Bowel Syndrome-Like Symptoms: A Joint Rome Foundation and International Organization for the Study of IBD (IOIBD) Consensus.
Gastroenterology · 1 Sept 2026 · Consensus Statement
A joint consensus defines "IBD with IBS-like symptoms" and recommends standardized evaluation and treatment strategies for patients in remission with persistent gastrointestinal symptoms.
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Desynchronization of intestinal circadian clocks and gastrointestinal dysfunction.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Consensus on Irritable Bowel Syndrome-Like Symptoms in Inflammatory Bowel Disease: A Step Toward Advancing Patient-Centered Care.
Gastroenterology · 1 Sept 2026 · Editorial
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Ten years of advances in disorders of gut-brain interaction.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Bridging Genetics and Bedside Decisions in Inflammatory Bowel Disease: Utility Metrics for Susceptibility Polygenic Scores.
Gastroenterology · 1 Sept 2026 · Letter
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The Rome V criteria for the diagnosis of irritable bowel syndrome in secondary care: a diagnostic accuracy study.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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Reply.
Gastroenterology · 1 Sept 2026 · Letter
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Precision Medicine in Inflammatory Bowel Disease: Are We There Yet?
Gastroenterology · 24 Aug 2026 · Journal Article
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Diet in IBD: preventive and therapeutic concepts.
Gut · 21 Aug 2026 · Review
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Accessibility versus efficacy: interpreting the non-inferiority trial of digital hypnotherapy in IBS.
Gut · 19 Aug 2026 · Letter
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