The small intestine microbiome: composition, host interactions and therapeutic potential.

Nature Reviews Microbiology · 10 Nov 2026 · Review

Nachman, Wozniak + more

The abstract is read at the publisher; the summary is JClub's.

The small intestine microbiome is positioned as a distinct, understudied source of microbial therapeutics, with its host–diet interactions offering opportunities beyond fecal-focused research.

Why it matters: Most gut microbiome work has relied on fecal communities, leaving the small intestine’s distinct environment and host interactions insufficiently characterized for therapeutic development.
What they did: This Review synthesizes current knowledge on small intestine microbial composition and host physiology links, and outlines how next-generation microbial therapeutics could be derived from small intestinal communities.
The result: Small intestinal microorganisms are anticipated to enable novel microbial therapeutics relevant to improving small intestinal diseases and broader systemic human health.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

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The small intestine microbiome: composition, host interactions and therapeutic potential.

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