Satellite glial translatome reprograms to favor mitochondrial and vesicular signaling under pelvic pain conditions

In sensory satellite glial cells from chronic pelvic pain (CPP) mice, translating mRNAs shift toward mitochondrial and vesicular signaling, with immune gene suppression and sex-specific differences.

• Why it matters: Satellite glial cells shape inflammatory and neuropathic pain, but their translational programs in pelvic pain—and how these differ by sex—were not defined.
• What they did: Using translating ribosome affinity purification followed by RNA sequencing (TRAP-seq), the study profiled active translating mRNAs in sensory SGCs from CPP mice, linking reprogramming to eukaryotic translation initiation factor 4E (Eif4e).
• The result: CPP conditions increased translation of mitochondrial and vesicular genes and suppressed immune genes in both sexes, and female pelvic sensory ganglia showed an anti-inflammatory cytokine profile, suggesting mitochondrial/vesicular translation may support afferent hypersensitivity.

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