Dendritic cell metabolism in cancer and immunity.

Metabolic checkpoints shape dendritic cell biology, linking nutrient-driven signaling and DC–tissue metabolic crosstalk to immunogenic versus tolerogenic function across cancer and other immune settings.

• Why it matters: Immune-mediated diseases depend on how dendritic cells coordinate responses, yet the specific metabolic programs and metabolite cues that govern DC function remain a key translational gap.
• What they did: This Review synthesizes evidence on how metabolic programs regulate dendritic cell immunogenic and tolerogenic functions, how extracellular nutrients and metabolites drive intracellular signaling, and how DC metabolism interacts bidirectionally with the tissue microenvironment.
• The result: The integrated view suggests that understanding dendritic cell metabolic processes has strong translational potential for treating immune-mediated diseases, including cancer, autoimmunity, and metabolic disorders.

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