Myeloid cells run amok in injured brains.

Aberrant cranial bone marrow-derived myelopoiesis in chronic traumatic brain injury is linked to neuroinflammation.

• Why it matters: Chronic traumatic brain injury involves persistent neuroinflammation, but the specific bone marrow–myeloid contribution is not fully defined.
• What they did: The work focuses on how injured brains generate abnormal cranial bone marrow-derived myelopoiesis and examines its role in neuroinflammation.
• The result: The findings indicate that dysregulated myeloid production is associated with neuroinflammation, supporting a bone marrow–myeloid target in chronic traumatic brain injury.

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