Engineered GPCR-based yeast biosensors have achieved significant performance improvements, enabling diverse practical applications through modular design and optimization.
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Receptor Mechanisms and Signaling
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Blocking cholinergic interneurons in the nucleus accumbens prevents opioid-reward learning without affecting dopamine signaling, revealing a key cholinergic gate.
11.3% of randomly modified ligands across six targets improved potency tenfold or more, revealing a surprising baseline for ligand optimization success.
- Open access
Norepinephrine and dopamine sensors in mouse brains exhibit cross-activation dependent on local innervation density, complicating neuromodulatory signaling interpretation.
- Open access
Engineered GPCR-based yeast biosensors have achieved significant performance improvements, enabling diverse practical applications through modular design and optimization.
- 1 opens in JClub
TM184C, a conserved GPCR-like protein, regulates intercellular exchange and autophagy by localizing to vesicles and forming intercellular connections in human cells.
- Open access
- 1 cites
CD97/ADGRE5 suppresses early immune activation, reducing airway inflammation in allergic asthma, with deficiency leading to a 2-fold increase in disease severity.
- Open access
Core promoters function as active gatekeepers, restricting enhancer inputs to generate precise spatiotemporal gene expression patterns in Drosophila.
- Open access
- 1 cites
Beta-adrenergic receptor (β2AR) endosomal signaling induces dendritic growth and synapse formation in neurons, orchestrating gene regulation and cellular architecture.
- Open access
Viral receptors function as dynamic regulatory hubs influencing entry, signalling, and systemic disease, with receptor landscapes shaping viral tropism and severity.
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