Necroptosis involves two distinct subtypes, extrinsic and intrinsic, with over 50% of pathways triggered by membrane receptors or intracellular sensors.
Nuclear Structure and Function
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FBXL21 controls diurnal proteostasis in skeletal muscle by degrading DNAJB6 and its client proteins, with mutations conferring resistance and disrupting protein balance.
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Programmable DNA protonuclei reveal that environmental factors like confinement and viscoelasticity critically influence FUS protein phase separation, with a significant impact on disease-related transitions.
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The transactivation domain (TAD) is essential for nuclear import of phosphorylated STAT5, with two key residues D754 and D758 critical for this process.
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Clathrin adaptors Ent5 and Sla2 drive phase separation essential for membrane trafficking, with Ent5's helix and Sla2's coiled-coil mediating condensate formation.
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A novel ∼54-kDa protein, MSEP, encoded by the ARHGEF17-AS1 locus, is essential for mitotic spindle organization and localizes to spindle poles.
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Mitotic slippage uniquely causes nuclear instability in whole-genome duplication, leading to highly variable nuclear deformations and altered genome organization.
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γ-tubulin associates with centromeres and influences their dynamics, with levels affecting centromere organization and response to genomic stress in human cells.
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Condensins, topoisomerase IIα, and physical forces collaboratively drive dynamic mitotic chromosome assembly, with condensin-mediated looping being central to the process.
Intercellular mitochondrial transfer via tunnelling nanotubes enables mitochondrial regeneration and rescue in cells with import dysfunction, involving distinct degradation pathways for different mitochondria.
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Vimentin loss impairs DNA repair and increases cancer cell survival under genotoxic stress, especially in glioblastoma cells, by disrupting nuclear mechanics.
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A conserved membrane fusion mechanism involving Brl1, Brr6, and CLCC1 drives nuclear pore complex assembly across eukaryotes.
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ZmSk2 is essential for maize kernel development, as its disruption causes severe arrest and impairs mitochondrial complex assembly and activity.
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Long-lived intron-retained RNAs at nuclear speckle periphery are regulated during mitosis, with 20% of transcripts involved in genome maintenance and mitosis.
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Disruption of basal body docking causes centriole clustering and elimination, leading to male infertility in mammalian spermatogenesis, with 100% of affected cells showing these defects.
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