Nature Reviews Molecular Cell Biology · 1 Oct 2026 · Journal Article

Factories, clusters, hubs, condensates - many names, one principle.

Vartak

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Mechanisms, regulation and clinical relevance of necroptosis.
Nature Reviews Molecular Cell Biology · 1 Oct 2026 · Review
Necroptosis involves two distinct subtypes, extrinsic and intrinsic, with over 50% of pathways triggered by membrane receptors or intracellular sensors.
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FBXL21 regulates diurnal proteostasis in skeletal muscle by targeting DNAJB6 and client proteins.
EMBO Reports · 30 Sept 2026 · Journal Article
FBXL21 controls diurnal proteostasis in skeletal muscle by degrading DNAJB6 and its client proteins, with mutations conferring resistance and disrupting protein balance.
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Programmable DNA protonuclei reveal environmental context on protein phase separation.
Nature Communications · 30 Sept 2026 · Journal Article
Programmable DNA protonuclei reveal that environmental factors like confinement and viscoelasticity critically influence FUS protein phase separation, with a significant impact on disease-related transitions.
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