The TUBG meshwork is associated with centromere dynamics and micronuclear organization.

γ-tubulin associates with centromeres and influences their dynamics, with levels affecting centromere organization and response to genomic stress in human cells.

• Why it matters: Understanding how γ-tubulin contributes to centromere behavior is crucial because it plays a role beyond microtubule nucleation, impacting chromatin organization and genome stability under stress.
• What they did: The study used live-cell imaging, immunofluorescence, and chromatin immunoprecipitation sequencing to analyze γ-tubulin localization and function in interphase cells, including stress conditions and cancer models.
• The result: Findings reveal γ-tubulin’s enrichment at centromeres, its role in regulating centromere mobility and clustering, and its accumulation in micronuclei, suggesting it supports chromatin organization and stress responses.