The abstract is read at the publisher; the summary is JClub's.
ADMETatlas curates 39,641 peptide ADMET measurements across 17 endpoints for 37,467 canonical peptide identities, linking each value to its tested material and assay context.
- Why it matters: Peptide permeability and in vivo stability often limit clinical progress, but reported ADMET values are hard to compare because they depend on molecular form and experimental context.
- What they did: The team built a freely accessible, curated database that preserves each measurement’s unit, formal endpoint, assay context, and primary reference, and cross-links identities, forms, and products.
- The result: A developability module profiles single candidates and enables side-by-side comparisons, and example analyses for GLP-1 receptor agonists and polymyxin B show route and formulation can change peptide pharmacokinetic interpretation.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.