PubChem 2027 update.

PubChem has expanded its chemical information coverage with over 100 new data sources and introduced RefChem to improve annotation mapping and access to non-discrete substances.

• Why it matters: Users need more comprehensive, better-curated chemical records and clearer mapping when substances have ambiguous or non-discrete structures.
• What they did: The update adds RefChem, enhances Quick Search and Advanced Search, introduces a Search History page with Boolean query building, and upgrades Classification Browser, Co-occurrence Panels, and PubChemRDF.
• The result: These changes broaden data coverage, strengthen search and interoperability (including improved PubChemRDF performance), and provide guidance for efficient cloud use.

AI summary of the abstract · may contain errors · not medical advice · read the paper.