KinaseMD 2.0: an updated database of kinase mutations and drug response.

KinaseMD 2.0 expands kinase mutation and drug-response coverage by integrating new substructure annotations, growing from 1162 to 13,522 and kinase coverage from 388 to 547.

• Why it matters: Kinase mutations can reshape inhibitor response and downstream phosphorylation signaling, especially in resistance-associated substructures, but prior databases lacked breadth and standardized evidence mapping.
• What they did: The update combines source-curated annotations with Dr. Kinase predictions, adds pharmacogenomic and signaling layers (422,244 drug-response measurements; 359,600 predicted rewiring events), and introduces KPEM using LLM literature extraction from 480,000+ publications plus 30 phosphoproteomic datasets.
• The result: It outputs 23,757 literature-supported kinase evidence records and 53,029 phosphoproteomic records across 5,124 drug/agent categories and 1,598 disease contexts, separating reported phosphorylation evidence from inferred signaling responses.

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