MobiDB in 2027: machine-actionable access to intrinsic protein disorder knowledge.

MobiDB’s 2027 release provides a more representative estimate of long-disorder across UniProtKB reference proteomes, with median residue coverage of 12.3% in eukaryotes.

• Why it matters: Intrinsic disorder annotations need consistent semantics and machine-accessible provenance so evidence can be retrieved, combined, and reused reliably at scale.
• What they did: The team refined a hierarchical controlled vocabulary, added a versioned REST API plus an MCP server for documented programmatic operations, and updated production and interaction-processing workflows.
• The result: Long-disorder prevalence is quantified across eukaryotes, archaea, bacteria, and viruses (12.3%, 1.9%, 1.7%, 3.4% median residue coverage), enabling easier discovery, functional linkage, and reproducible reuse with explicit provenance.

AI summary of the abstract · may contain errors · not medical advice · read the paper.