CATH and TED in 2026: expansion in the number and diversity of CATH superfamilies.

CATH expands its protein structural domain coverage by integrating experimentally determined PDB structures with rapidly growing AlphaFold predicted structures, alongside new homology detection and automated end-to-end workflows.

• Why it matters: The field needs scalable, up-to-date domain annotation that keeps pace with both experimental structure growth and large-scale predicted structure collections.
• What they did: The authors update CATH by adding AlphaFold Protein Structure Database predictions via The Encyclopedia of Domains and improving homology detection protocols and automated workflows for end-to-end domain annotation and classification.
• The result: These advances enable CATH to process large-scale protein structural data more effectively, strengthening its integrated evolutionary, structural, and functional annotation and visualization capabilities.

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