PANTHER: the protein tree and function resource in 2027.

PANTHER updates expand manually annotated phylogenetic protein family trees across 131 genomes, increasing GO coverage by 20%–100% and enabling tree-based GO annotation generation for sequence files.

• Why it matters: Existing protein function models need broader, more stable evolutionary coverage so gene lists and new sequences can be annotated consistently using evolutionary relationships.
• What they did: The team expanded GO annotations on PANTHER trees, revised thousands of families and added ~100, and modified the release pipeline to improve cross-version tree stability.
• The result: Users can download expanded annotations for all 131 genomes or analyze gene lists on the PANTHER website, and can generate tree-based GO annotations from any sequence file using InterProScan.

AI summary of the abstract · may contain errors · not medical advice · read the paper.