proMGE2-a planetary-scale resource of mobile genetic elements in microbial (meta)genomes.

proMGE2 expands the prokaryotic mobile genetic elements catalog to >16.4 million MGEs from 670k isolate genomes and 180k MAGs, enabling standardized MGE identification.

• Why it matters: Mobile genetic elements shape intercellular spread and antimicrobial resistance, but existing references are too limited to capture diversity across habitats and genome types.
• What they did: The team built proMGE2 with a 6X expansion, compiling MGEs across transposons, insertion sequences, phages, conjugative elements, mobility islands, and integrons, including ~50k environmental microbiome MAG samples.
• The result: proMGE2 provides a standardized reference of >5 million non-redundant MGE sequences and supports detection of MGEs in user genomes, scaling studies of genetic transfer in microbes.

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