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Molecular characterisation of a Klebsiella pneumoniae neonatal sepsis outbreak in a rural Gambian hospital: a retrospective genomic epidemiology investigation
medRxiv · · Preprint · Open access
Foster-Nyarko, Bah + 11 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Klebsiella pneumoniae ST39 with capsular locus KL62 drove a neonatal sepsis outbreak in a rural Gambian hospital, accounting for 29 cases and 16 fatalities.
- Why it matters: Hospital-acquired neonatal K. pneumoniae sepsis in Africa is often linked to outbreaks, but genomic confirmation of the specific strain and contamination sources is needed to refine control efforts and fatality estimates.
- What they did: They retrospectively sequenced 51 patient blood-culture K. pneumoniae isolates (77% from neonates), 16 outbreak environmental isolates, and 56 stored surveillance isolates using ONT Mk10/PromethION, then compared genomes to local and global ST39 data.
- The result: The outbreak strain was found in three intravenous-fluid samples from the neonatal ward, carried an ~187 kbp IncF plasmid with blaCTX-M-15 and aac(3)-IId, and was absent from historical local surveillance.
The findingWhy it mattersWhat they didThe result
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