VirulenceJClub
Comparative genomics of carbapenem resistance and virulence associated with respiratory tract and bloodstream infections in carbapenem-resistant Klebsiella pneumoniae.
Virulence · · Comparative Study
Liu, Shen + more
Abstract ↗AI summary
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Longitudinal surveillance of 282 carbapenem-resistant Klebsiella pneumoniae isolates (225 sputum, 57 blood) found ST11-CG258 dominance (77.3%) and source-linked capsular and plasmid evolution.
- Why it matters: Resistance and hypervirulence in CRKP are a global threat, but the genomic adaptations that differ by infection source are not well defined.
- What they did: Whole-genome surveillance (2021–2024) compared respiratory versus bloodstream isolates, tracking capsular shifts within ST11 and plasmid clustering, including carbapenem-resistant Aclusters 1–6 and hypervirulent Vclusters 1–2.
- The result: Bloodstream isolates were enriched for energy and amino-acid transport genes, while sputum isolates showed enrichment for DNA repair and insertion sequences; hybrid plasmids in Acluster 1 co-carried bla KPC-2 with iucABCD-iutA, rmpA, and peg-344.
The findingWhy it mattersWhat they didThe result
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