Bidirectional actomyosin redistribution drives epithelial invagination, with 2 distinct phases involving apical constriction and lateral contractility in ascidian siphon tube development.
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Developmental Biology and Gene Regulation
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Latest in Developmental Biology and Gene Regulation
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Genome-wide mapping reveals conserved cis-regulatory elements in the 3.6 Gbp genome of Parhyale hawaiensis, enabling more efficient identification of functional DNA regions.
- Open access
Pioneer transcription factor ETS1 primes histone activation and drives 3D genome reorganization during osteoblast differentiation, with B-to-A chromatin shifts pre-marked in pre-osteoblasts.
- Open access
Genetic factor analysis reveals 15 pleiotropic components underlying 22 risk factors for coronary artery disease and type 2 diabetes.
Region-specific mechanosensory neurons regulated by Hox genes are essential for Drosophila larva self-righting, with anterior inhibition increasing head casting and prolonging recovery times.
- Open access
Canonical Notch2 signaling is essential for the development, maintenance, and function of iron-recycling macrophages, with its disruption causing iron overload in mice.
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Gene-regulatory changes in over 15,000 loci drove extensive remodeling of the human skeletal extracellular matrix, including a three-to-fourfold reduction in joint GAG content.
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Stepwise assembly of transcriptional condensates enables graded 3D genome reorganization during yeast heat shock response.
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Two distinct neural ectoderm progenitors independently generate the forebrain/midbrain and hindbrain regions in mouse and human development.
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Synergistic inhibition of Notch signaling and forced cell cycle re-entry induces significant Müller glia reprogramming, generating diverse retinal neuron-like cells in uninjured mouse retina.
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Color patterns in vertebrates reveal key developmental principles that drive phenotypic diversity, with self-organization and instruction guiding pattern evolution.
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Single-nucleus transcriptomic atlas reveals key cell types and developmental mechanisms in human inner ear, highlighting vulnerabilities linked to disease genes.
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Centrosome migration and apical membrane formation are hierarchically related but can occur independently during epithelial polarization in MDCK cysts, with centrosome positioning influenced by Par3.
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