The abstract is read at the publisher; the summary is JClub's.
In Schmidtea mediterranea, sublethal irradiation reversibly suppresses whole-body regeneration, and activin-2 depletion restores amputation-driven stem cell proliferation and tissue regrowth.
- Why it matters: Regeneration after damage often fails, but it is unclear whether surviving stem cells lose regenerative ability or whether tissue-derived signals actively restrain their deployment.
- What they did: After irradiation, the authors used single-cell transcriptomics to track regeneration-activated cell states and measured activin ligand and follistatin changes, then depleted activin-2 and tested regeneration after irradiation and cisplatin.
- The result: Activin signaling is linked to a reversible restraint: activin-2 depletion restored amputation-induced proliferation and regeneration after prior irradiation and improved recovery after cisplatin exposure.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.