Remnants of repetitive DNA shape the earliest stages of de novo gene evolution in insects

bioRxiv · 12 Nov 2026 · Preprint · Open access

Sanno, Satomura + 10 more

The abstract is read at the publisher; the summary is JClub's.

In the cricket Teleogryllus occipitalis, 41 de novo gene candidates from intergenic DNA show young-gene features and often include transposable-element fragments and simple sequence repeats.

Why it matters: It remains unclear how noncoding DNA becomes fixed as new genes within stable gene repertoires, especially during the earliest stages of de novo gene emergence.
What they did: The study used chromosome-scale genome assemblies from Teleogryllus occipitalis and Tarbinskiellus portentosus and comparative genomics to identify 41 conservative de novo candidates and assess repetitive fragments across insect evolution.
The result: About 24% of insect gene families retained since the last common ancestor contain repetitive sequence fragments, and older genes show positional correspondence despite divergence, implying constraints on incorporating repeats increase after establishment.

AI summary of the abstract · may contain errors · not medical advice · read the paper.

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Aevol-9: A simulation platform to decipher the evolution of genome architecture
bioRxiv · 11 Nov 2026 · Preprint
AI summary · may contain errors
Aevol is a forward-in-time simulator that models genome architecture evolution by explicitly tracking both genome sequence and structure under mutational operators, including large-scale rearrangements.
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- 2 cites
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https://jclub.com.au/a/10.1101/2025.04.10.648095
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RICO enables integrated analysis of ribosomal DNA copy number and methylation from nanopore long-read sequencing
bioRxiv · 10 Nov 2026 · Preprint
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RICO enables integrated estimation of ribosomal DNA copy number and methylation from Oxford Nanopore long reads, accurately quantifying rDNA CN and capturing ~40% CN changes in Atrx-knockout mouse embryonic stem cells.
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https://jclub.com.au/a/10.64898/2026.07.05.736662
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A chromosome-level, haplotype-resolved genome assembly of the impressed tortoise, Manouria impressa
bioRxiv · 10 Nov 2026 · Preprint
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A chromosome-level, haplotype-resolved genome for the impressed tortoise Manouria impressa was assembled, placing 94.5% of sequence into 26 chromosomes (2n = 52).
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https://jclub.com.au/a/10.1101/2025.03.10.642296
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Remnants of repetitive DNA shape the earliest stages of de novo gene evolution in insects

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