Aevol-9: A simulation platform to decipher the evolution of genome architecture

Aevol is a forward-in-time simulator that models genome architecture evolution by explicitly tracking both genome sequence and structure under mutational operators, including large-scale rearrangements.

• Why it matters: Understanding how evolutionary conditions shape genome organization is difficult to test directly, so a controllable in silico system is needed to probe these effects systematically.
• What they did: Aevol simulates a population of individuals with explicit genomes whose sequence and architecture are altered by substitutions, indels, and large-scale chromosomal rearrangements, enabling controlled evolutionary “experiments.”
• The result: By varying evolutionary conditions such as population size, selection strength, mutation rates, and biases, Aevol can decipher how these factors are linked to changes in genome organization.

AI summary of the abstract · may contain errors · not medical advice · read the paper.