Genome-wide mapping reveals conserved cis-regulatory elements in the 3.6 Gbp genome of Parhyale hawaiensis, enabling more efficient identification of functional DNA regions.
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Chromosomal and Genetic Variations
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Latest in Chromosomal and Genetic Variations
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Kilobase-sized indels and point mutations drive centromere evolution in Arabidopsis thaliana, with point mutations occurring nearly ten times faster than elsewhere in the genome.
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Specialized reader proteins and transcription factors interpret DNA methylation to regulate gene expression and chromatin structure in mammals and plants.
γ-tubulin associates with centromeres and influences their dynamics, with levels affecting centromere organization and response to genomic stress in human cells.
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exhibits obligate, genome-wide achiasmy in both sexes, resulting in offspring that are genetically identical and mimicking clonal reproduction despite sexual meiosis.
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Prime assembly achieves targeted integration and large-scale genomic rearrangements in human cells without relying on double-stranded DNA donors or cell cycle cues.
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African genomes encompass over 1.4 billion individuals and contain more genetic variation than the rest of the world combined, yet only about 1% of genomes in major databases are of African ancestry.
Genetic variants in Arabidopsis thaliana significantly influence repeat content divergence, with over 50 loci linked to genome-wide repeat abundance variation.
- Open access
Zinc-finger proteins C3H14 and C3H15 are essential for maintaining meiocyte identity in flowering plants, with mutations causing meiotic arrest and cell death.
Programmable enzymes, especially CRISPR-associated transposases, now enable kilobase-scale gene insertions, surpassing previous limitations of small-scale editing methods.
CENP-C is essential for kinetochore recruitment and CID assembly during Drosophila male meiosis, with distinct pools supporting centromere function at different stages.
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