Nature Reviews Genetics
Nature Portfolio · Genomics & Bioinformatics · ISSN 1471-0056, 1471-0064
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Multimodal lineage tracing combined with advanced computational methods enables detailed reconstruction of cellular development with high accuracy and resolution.
Genetic variation and misalignment of the circadian clock significantly influence human health, disease risk, and treatment outcomes, highlighting the importance of temporal biology.
Sequence-based deep learning predicts genetic variant effects at base-pair resolution, enabling precision breeding in crops and overcoming evolutionary constraints.
Cohesin's dual functions in genome maintenance include sister chromatid cohesion and chromatin loop extrusion, crucial for DNA repair and genome stability.
Machine learning and advanced statistical methods enhance molecular QTL mapping, increasing power to link genetic variants to molecular traits in large cohorts.
Specialized reader proteins and transcription factors interpret DNA methylation to regulate gene expression and chromatin structure in mammals and plants.
Extrachromosomal DNA and plasmids share key evolutionary functions, enabling rapid adaptation across bacteria and cancer cells, with ecDNA exhibiting similar dynamics to plasmids.
Genomic analyses reveal recent human evolution has been shaped by natural selection, with new methods uncovering detailed signatures over the past 10,000 years.
Genomic and genetic tools have established danionin fishes, including Danio rerio, as key models for studying evolutionary trait divergence, with recent genomes revealing species-specific traits.
Programmed DNA elimination occurs across diverse eukaryotes with significant mechanistic diversity and evolutionary recurrence, affecting genome integrity and cellular processes.
Programmable enzymes, especially CRISPR-associated transposases, now enable kilobase-scale gene insertions, surpassing previous limitations of small-scale editing methods.
Multi-omic approaches and miniaturization are transforming liquid biopsies, enhancing sensitivity and enabling real-time, minimally invasive cancer monitoring.
Telomere attrition acts as a key tumor-suppressor mechanism, preventing cancer by depleting telomeric DNA and halting cell proliferation in early tumor development.
Multiple temperature signals are integrated through chromatin memory mechanisms to regulate flowering time in plants, ensuring adaptation to climate variability.
Genomic advances have identified causal genes and variants, paving the way for targeted therapies for retinal and macular degeneration affecting millions globally.
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Evolutionary forces have shaped the genetic architecture of aging, leading to the accumulation of late-acting deleterious mutations and conserved longevity pathways across species.
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Moving areas, week to 3 Oct 2026
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