A conserved CNBHD-CNBHD interface in KCNH channels restrains activation, with mutations like G574E in EGL-2 enhancing activity to suppress sleep in C. elegans.
PLOS Genetics
Public Library of Science · Genomics & Bioinformatics · ISSN 1553-7390, 1553-7404
- Impact (2-yr)
- 4.5
- h-index
- 352
- Open access
- 100%
- Works
- 11.8K
- Papers this month
- 26
Rebuilt
Latest in PLoS Genet
Newest first · last 60 days
Incorporating protein misfolding stability into Bayesian models identifies over 28,000 likely pathogenic deafness variants, revealing a key disease mechanism.
Genetic mediation by six immune markers explains 11 immune-psychiatric disease links, with IL-6 mediating 60% of the internalizing factor's connection to Crohn's disease.
Gradual, recurrent adaptation to protein malnutrition in zebrafish involves genome-wide transcriptional changes that enhance intestinal function and survival.
Alterations in the FtsI pedestal domain modulate β-lactam susceptibility and cell division regulation in Pseudomonas aeruginosa, revealing a key regulatory hub.
lin-15A acts as a transdifferentiation Licenser in C. elegans by antagonizing identity safeguarding mechanisms, enabling rectal-to-neuronal cell conversion.
Drosophila Mettl16 mutants are viable but exhibit severe developmental, behavioral, and fertility defects, with specific impacts on gametogenesis and splicing regulation.
UniLasso achieves sparse, interpretable polygenic risk scores with comparable accuracy to Lasso in UK Biobank data, selecting significantly fewer variants.
METTL1-mediated m7G modification is essential for hair follicle cycling, with Mettl1 knockout causing severe dysplasia and delayed regeneration in mice.
GALT-null rat fetuses develop elevated galactose metabolites and growth delays, but maternal heterozygosity can partially mitigate these prenatal effects.
Bacterial gene positioning is shaped by selection on both mean and growth-dependent expression, with gradients observed across multiple species and conditions.
Disruption of key DNA repair genes recA and uvrD significantly impairs fluoroquinolone persister recovery in Escherichia coli, highlighting their crucial roles in DNA repair mechanisms.
Xrp1 plays dual roles in genome integrity by mediating p53-dependent DNA damage response and p53-independent cell competition in Drosophila.
Shared genetic risk across cancers is concentrated in 82 specific regions and five cancer clusters, with significant functional enrichment in immune-related pathways.
Genetic associations with educational milestones peak at high-school to bachelor's transition, then decline at postgraduate levels, revealing distinct genetic influences across educational stages.
- Open access
Arginine kinase 1 is essential for Drosophila flight muscle development, supporting energy homeostasis and sarcomere maturation with a critical role in muscle growth.
- Open access
Less than 1% of autosomal SNPs show significant Hardy-Weinberg deviations in the 1000 Genomes Project, with most linked to poor sequence quality.
Outer membrane proteins facilitate unconventional secretion of DypB2985 in Pseudomonas putida via crosstalk between Sec pathway and OMVs.
Sediment-associated Shewanella baltica strains exhibit extensive genomic diversification, forming three distinct evolutionary groups with 'sexual' recombination-driven divergence.
EFN-4/Ephrin, along with SAX-3/Robo, UNC-6/Netrin, and HSPGs, forms an extracellular signaling complex essential for posterior Q neuroblast migration in C. elegans, with a key role in PQR neuron placement.
APOE ε4 influences cholesterol, immunity, and reproduction differently across industrialized and non-industrial environments, with effects varying by lifestyle and population.
ER-to-Golgi trafficking proteins ERGI-2 and ERGI-3 specifically activate the IRE-1-XBP-1 UPR pathway in response to excessive UNC-9 in C. elegans neurons.
FM-GPT accurately prioritizes causal genes across multiple phenotypes, reducing candidate sets by up to 80% in phenome-wide TWAS analyses.
European amphioxus (Branchiostoma lanceolatum) exhibits an exceptionally high genomic heterozygosity of 2.73%, indicating extensive genetic diversity across its range.
Low-coverage whole-genome sequencing identified 17 new apomictic Malus genotypes in a USDA germplasm collection, advancing tools for plant breeding.
A RPA-Trt1TERT-Tpz1TPP1 complex in fission yeast enhances telomere extension and prevents recombination, revealing four critical interaction interfaces.
OsDUF1223 negatively impacts drought tolerance and nitrate-dependent root growth in rice seedlings, reducing survival rates under drought stress.
The SigD regulon in Mycobacterium abscessus controls cell envelope composition and increases susceptibility to hydrophobic antibiotics, with 447 genes differentially expressed.
MicroRNA and IRE-mediated regulation of Pfn2 controls embryonic stem cell differentiation, with deletion of these sites causing significant signaling defects.
Nanopore sequencing reveals a significant reduction in m6A modifications across human transcripts following METTL3/14 depletion, highlighting their distinct roles in RNA regulation.
Follow PLoS Genet in the app
Browse JClub
Journals this month
- bioRxiv5569
- medRxiv1738
- Environ Res483
- PNAS463
- Sci Adv439
- JAMA255
- Cell Rep210
- BMJ199
- Nat Commun177
- Environ Pollution170
- Lancet149
- Science138
- NEJM119
- Applied & Environ Microbio116
- J Exp Bot115
- Curr Biol112
- mBio109
- Nature104
Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4