The lipid raft marker flotillin FloA drives relocalization of the plasma membrane H+-ATPase PmaA as a protective response to calcium stress.

In Aspergillus nidulans, flotillin FloA is essential for PmaA internalization during calcium stress, preventing intracellular calcium overload and cell death.

• Why it matters: Lipid raft marker functions are unclear, and calcium stress requires membrane remodeling; the role of flotillin in coordinating protective trafficking is unresolved.
• What they did: FloA expression was measured under calcium stress, BioID mapped FloA proximity partners including PmaA, and PmaA internalization and viability were compared between wild type and ΔfloA.
• The result: Calcium stress upregulates FloA, and deleting floA prevents PmaA internalization and causes cell death; blocking endocytosis during calcium stress reproduces the ΔfloA phenotype.

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