The abstract is read at the publisher; the summary is JClub's.
Growth rate–dependent negative feedback, without sensing organ size, corrects size in Drosophila wing imaginal discs when growth rate changes early in the growth period.
- Why it matters: Organ size determination mechanisms are still unclear, and it is unknown how discs compensate for different growth trajectories to reach the needed size on time.
- What they did: The study proposes a model for wing imaginal discs in which negative feedback depends on growth rate rather than organ size, and tests it by altering size before versus growth rate during the start of growth.
- The result: Size changes before the growth period are not corrected, whereas early growth-rate alterations trigger size-correcting feedback, enabling compensation for trajectory differences and estimation of the average growth trend needed.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.