Transformer-based language models have the potential to revolutionize bioinformatics by addressing complex challenges across genomics, transcriptomics, proteomics, and drug discovery.
- Open access
- 29 cites
RNA modifications and cancer
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ALKBH5-driven epitranscriptomic changes in cancer-associated fibroblasts promote pancreatic cancer metastasis independently of primary tumor growth.
- Open access
AHA, a conserved archaeal ribosome-associated protein, links bacterial hibernation factors and eukaryotic energy sensors, revealing an evolutionary connection across domains.
- Open access
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis severity by enhancing ECM remodeling and protecting enteric neurons, with a 50% decrease in inflammation.
Dietary unsaturated fatty acids differentially influence pancreatic cancer progression by modulating ferroptosis sensitivity, with MUFAs promoting and PUFAs inhibiting tumor development.
- Open access
- 1 cites
Coliphage HY126 encodes a novel dual cytosine modification system involving hydroxylation and diarabinofuranosylation, creating a unique DNA modification with two arabinofuranose units.
- 2 cites
Cell surface RNA-binding proteins are emerging as potential biomarkers and immunotherapy targets, with specificities linked to cell type and disease, including cancer.
IGF2BP1 directly binds HBG1/2 transcripts and activates HIC2, revealing a dual mechanism regulating fetal hemoglobin expression.
- Open access
- 1 cites
A human cell-free translation screen identified NT-2 as a novel ribosomal inhibitor binding the peptidyl transferase center, disrupting mammalian protein synthesis.
- Open access
Reduced nascent rRNA synthesis drives nucleolar reorganization under stress, altering sub-structures and biophysical properties in Homo sapiens cells.
- Open access
Deletion of mraW reduces translation efficiency by approximately twofold in Bacillus subtilis ribosomes, correcting a sporulation defect and bypassing a checkpoint.
- Open access
- 1 cites
EBV-encoded v-snoRNA1 guides 2'-O-methylation of human rRNAs at conserved sites, reducing translation and slowing cell proliferation to regulate viral latency and lytic switch.
- Open access
ARHGEF17-AS1 is essential for mitotic spindle integrity, regulating spindle organization through interactions with RPS3, dynein, and RNF10 during mitosis.
- Open access
NAD+ precursor treatment improves cardiac function but impairs erythroid maturation in mitochondrial progeria mice, revealing tissue-specific effects.
- Open access
Cryo-EM reveals the atomic structure of the human tRNA ligase complex, showing how non-catalytic subunits assemble to facilitate tRNA splicing.
- Open access
Ashwin (ASW) directs nuclear localization of tRNA ligase complex, with FAM98 paralogs determining its cytoplasmic or nuclear form, crucial for tRNA and mRNA splicing.
- Open access
High IGF2BP2 expression drives tumor growth and immune evasion in PTCL, with overexpression observed in 3 independent cohorts and 196 patient samples.
- Open access
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