Suprachoroidal delivery of AL-001 achieves sustained aflibercept expression and superior efficacy with minimal inflammation in a nonhuman primate model of wet age-related macular degeneration.
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Frontiers in Genetics
Frontiers Media · Genomics & Bioinformatics · ISSN 1664-8021
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S1PR1, CA2, and ABCG2 are identified as key ion homeostasis-related genes with strong diagnostic potential for pulmonary arterial hypertension, with S1PR1 showing protective effects.
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Combining radiotherapy with immunotherapy can enhance systemic antitumor immunity, but success depends on balancing local control with immune activation, with some approaches showing promise in specific cancers.
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Dose-dependent application of gibberellic acid and benzylaminopurine enhances photosynthesis and metabolic stability, conferring drought tolerance in pigeonpea with a 33.2% increase in PSII efficiency.
- Open access
Off-target drug repurposing offers a promising therapeutic strategy for rare cancers, with evidence supporting its potential in 20-50% of anticancer agents.
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Supplementing 1% Chinese herbal-microecological preparations significantly enhances growth, meat quality, and rumen microbiota in Simmental cattle over 120 days.
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Loss of LDHA in breast cancer cells disrupts R-loop homeostasis, causing increased R-loop accumulation and DNA damage, with 199 peaks rising and 81 decreasing.
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A structured methodological framework enables early-stage performance assessment of clinical variant classification platforms, demonstrated on 97 cases across three versions.
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Genomic abnormalities were identified in 10.3% of 107 Tunisian patients with corpus callosum abnormalities, highlighting the role of pathogenic CNVs in these disorders.
- Open access
A nomogram combining tumor-immune and nutritional biomarkers predicts 3-year recurrence with 84.1% accuracy after total colectomy for advanced colon cancer.
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AI-driven integration of multi-modal single-cell genomics and reverse vaccinology enables de novo design of personalized multi-epitope cancer vaccines, advancing immunotherapy.
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Altered m(6)A methylation patterns in mRNAs and lncRNAs are significantly associated with major depressive disorder, affecting over 600 RNAs in patient blood samples.
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A 9-gene signature predicts radiotherapy outcomes in hypopharyngeal squamous cell carcinoma with over 82% accuracy at 1 year.
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European Health Data Space and biobanking integration could create a trustworthy, federated health research infrastructure in Europe, but faces significant governance and technical challenges.
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Sixty-two percent of transgender adults are willing to participate in genomics research, but concerns about harm and mistrust remain significant barriers.
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A 2.06 Mb de novo deletion at 17p13.3p13.2 causes progressive neurodevelopmental decline in a Chinese patient with isolated lissencephaly sequence, highlighting PAFAH1B1 haploinsufficiency.
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Eighteen candidate TCDD-associated targets, including five hub genes, were identified in retinoblastoma, with CDK1 showing the strongest link to cell-cycle dysregulation.
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A hybrid development approach enabled creation of a comprehensive Boesenbergia rotunda genome database with 27 interconnected tables, supporting advanced genomics analysis.
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A de novo 15q11.1-q13.3 duplication with tetrasomy and trisomy was linked to severe neurodevelopmental delays and autism in a girl, expanding known genomic variations.
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Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
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Genomic analysis reveals a potential supergene architecture associated with human host-feeding behavior in Aedes aegypti mosquitoes, involving a specific inversion on chromosome 2.
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RSVA and RSVB induce distinct temporal and functional airway responses, with RSVA showing the strongest expansion and RSVB shifting from inflammation to interferon activity.
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Ultrasound radiomics combined with an immune-related gene signature predicts melanoma response to immune checkpoint inhibitors with 78-88% accuracy.
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Presymptomatic risdiplam led to significant motor improvements in preterm monozygotic twins with co-occurring SMA and TSC, marking the first such case report.
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A machine learning scoring system using metabolic biomarkers achieves an AUC of 0.910 for IBD diagnosis, surpassing traditional fecal calprotectin tests.
- Open access
HSTXGB achieves significantly better performance than eight state-of-the-art methods in inferring gene regulatory networks from time-course data, with improved accuracy demonstrated on multiple datasets.
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Heterogeneous resistance mechanisms, including EGFR mutations, bypass signaling, and transformation, emerge in EGFR T790M-positive lung adenocarcinoma after 14.2 months of osimertinib treatment.
- Open access
Upregulated SLC7A5 across thyroid cancer cell types highlights potential therapeutic targets, with significant expression in KTC-1 cells and interactions with key genes.
- Open access
Increased homozygosity significantly raises ACL rupture risk in Rottweilers but not in Labrador Retrievers, highlighting breed-specific genetic influences.
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Effective communication behaviors in clinical encounters can enhance trust and improve participation of underrepresented populations in biobanking, as shown by preliminary findings.
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