The abstract is read at the publisher; the summary is JClub's.
Immune hub genes CCR5, CSF1R, CD86, CD8A, and LCP2 are upregulated in clear cell renal cell carcinoma and form a ccRCC-linked M03 immune module.
- Why it matters: ccRCC shows metabolic reprogramming and immune heterogeneity, but immune-microenvironment markers tied to ferroptosis programs are not well defined for diagnosis or immune stratification.
- What they did: Using GSE53757, TCGA-KIRC, and single-cell RNA-seq (GSE159115), the team integrated differential expression, co-expression clustering, ferroptosis enrichment, immune scoring, and ROC testing, plus qRT-PCR in RPTEC, 786-O, and macrophage cultures.
- The result: TCGA-KIRC confirmed diagnostic discrimination with AUC 0.862–0.948 and a five-gene panel AUC of 0.932, while pathway/co-expression links to ferroptosis were supported but direct GPX4/SLC7A11 or iron/lipid-peroxidation regulation was not established.
The findingWhy it mattersWhat they didThe result
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