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Telomeres, Telomerase, and Senescence

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Latest in Telomeres, Telomerase, and Senescence

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Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
Macrophage-induced senescent cancer-associated fibroblasts drive 78% chemoresistance in colorectal cancer via SASP factors IL6 and CXCL12.
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https://jclub.com.au/a/42418705
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Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration.
Genome Medicine · 2 Oct 2026 · Journal Article
Blood cell composition accounts for up to 53% of variation in DNA methylation age, with distinct influences on epigenetic clock measures and biological processes.
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Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.10.724127
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Gap-free telomere-to-telomere haplotypes assembly of the hybrid grouper 'Yushuban' (Cromileptes altivelis female x Epinephelus fuscoguttatus male)
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752973
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Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753049
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A generator-matrix model quantifies the limited contribution of measured biomarkers to human mortality acceleration
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.05.26356402
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Skin commensals shape the clock-ferroptosis axis to preserve barrier function in psoriasis.
Cell Reports · 17 Sept 2026 · Journal Article
Lactobacillus plantarum and its metabolite indole-3-lactic acid restore skin barrier function by modulating the clock-ferroptosis axis in psoriasis.
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Senescent cell heterogeneity in brain aging and neurodegenerative disease.
Neuron · 16 Sept 2026 · Review
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Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence.
Nature Communications · 16 Sept 2026 · Journal Article
Proteome changes during replicative senescence are highly coordinated, with widespread chromatin protein depletion and increased mitochondrial insolubility, affecting cellular function.
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Complete Telomere-to-Telomere Assembly of the Y Chromosome in the Chinese Quartet
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.13.718326
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The impact of chronic exposure to cigarette and waterpipe smoke extracts on telomeres, telomerase, and cancer progression.
Frontiers in Genetics · 9 Sept 2026 · Journal Article
Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
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Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.
Nature Biotechnology · 7 Sept 2026 · Journal Article
Six proteomic aging clocks consistently predicted lower biological age in a 12-week clinical trial of rentosertib for idiopathic pulmonary fibrosis.
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Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.
Nature Communications · 4 Sept 2026 · Journal Article
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https://jclub.com.au/a/42697881
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Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.02.735775
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Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.
Genome Research · 1 Sept 2026 · Journal Article
Drosophila telomere transposons have repeatedly lost, gained, and horizontally transferred genes over 60 million years, showing dynamic convergent evolution and conflict with hosts.
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https://jclub.com.au/a/42386527
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The unbearable presence of senescent cells in ageing.
Nature Reviews Genetics · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42120717
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The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging.
Cell Metabolism · 1 Sept 2026 · Review
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https://jclub.com.au/a/42296967
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Telomere-to-Telomere Accurate and Gapless Korean Standard Reference Genome
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.17.688257
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MAPK13 controls structural remodeling and disease after epithelial injury
bioRxiv · 28 Aug 2026 · Preprint
MAPK13 regulates epithelial stem cell-driven remodeling and disease, with knockout mice showing protection against hyperplasia and immune activation after injury.
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https://jclub.com.au/a/10.1101/2024.05.31.596863
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A Measure of Transcriptional Dyscoordination for Quantifying Aging in Single Cells
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.24.701460
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Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.02.706451
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ELDR-Glo, a biosensor for cell age that correlates with quiescence depth
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.04.736063
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Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilities.
bioRxiv · 6 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.01.22.634421
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