The abstract is read at the publisher; the summary is JClub's.
Dietary HSP90 supplementation delivered by Escherichia coli significantly extends lifespan and healthspan in Caenorhabditis elegans without fertility trade-offs.
- Why it matters: Proteostasis decline is a key aging driver, and HSP90’s systemic role is unclear because inhibitors can extend lifespan across species.
- What they did: The study supplemented worms with dietary HSP90 via Escherichia coli, tested pathway activation of DAF-16, SKN-1, and HSF-1, combined it with tanespimycin, and engineered an antibiotic-free E. coli Nissle 1917 probiotic expressing HSP90.
- The result: Exogenous HSP90 is linked to extracellular signaling that engages kinase networks and activates multiple longevity transcription factors, and it shows an additive effect with tanespimycin, while the engineered probiotic also extends lifespan.
The findingWhy it mattersWhat they didThe result
AI summary of the abstract · may contain errors · not medical advice · read the paper.