Research area · week to 3 Oct 2026

Extracellular vesicles in disease

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Latest in Extracellular vesicles in disease

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Systemic health impact of cancer-associated extracellular vesicles and particles.
Nature Reviews Cancer · 1 Oct 2026 · Review
Cancer-associated extracellular vesicles and particles cause widespread systemic dysfunction, affecting multiple organs and contributing to disease progression and host mortality.
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Single molecule detection of Tau seeds in extracellular vesicles from Alzheimer's disease brains
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753085
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Increased extracellular fluid viscosity drives M2-like macrophage polarization to promote breast cancer progression and immunotherapy resistance.
Cell Reports · 24 Sept 2026 · Journal Article
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Circulating extracellular vesicle lipidomics identifies distinct signatures of amyotrophic lateral sclerosis and spinal muscular atrophy
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363372
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Epithelial-endothelial barrier dysfunction and oxidative stress in ARDS subphenotypes: comparative efficacy of extracellular vesicles derived from bone marrow (MSC-EVs) and adipose tissue (ASC-EVs) mesenchymal stem cells
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363677
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CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis
bioRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.08.584083
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Clostridium butyricum-derived extracellular vesicles alleviate ETEC K88-induced intestinal injury by regulating Wnt/β-catenin signaling and gut microbiota.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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Small Extracellular Vesicles from Gram-Negative Bacterial Infections Induce Myeloid Differentiation via p38 Signaling and Coordinate Antibacterial Defense Through the p38-IL-6 Axis
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.30.697125
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Extracellular membrane vesicles-previously unrecognized components of Staphylococcus aureus biofilms.
Journal of bacteriology · 17 Sept 2026 · Journal Article
Membrane vesicles are crucial biofilm matrix components in Staphylococcus aureus, significantly enhancing biofilm formation by carrying DNA and other matrix elements.
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Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.16.659944
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A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.30.728996
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Transparent Weighting of Heterogeneous Evidence for Auditable Candidate Prioritization
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.14.725271
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Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.05.709856
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Effect of seminal plasma extracellular vesicles in post-thaw functional parameters of cryopreserved ram sperm
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.17.732841
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EVd3x: A Bioinformatics Platform for Evidence-aware Interpretation of EV Cargo
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.06.723262
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Unveiling the Role of Extracellular Vesicles in HIV Infection: Molecular Mechanisms, Viral Persistence and Therapeutic Opportunities.
FEMS microbiology reviews · 7 Sept 2026 · Journal Article
Extracellular vesicles significantly influence HIV infection, contributing to viral persistence and immune modulation, with potential for targeted therapeutic interventions.
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https://jclub.com.au/a/42704642
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Multi-modal microRNA and non-targeted proteome analysis of liquid biopsies from the distal lung collected by Particles in Exhaled Air (PExA) reveal presence from extracellular vesicles
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.12.620657
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Myogenic differentiation-derived small extracellular vesicles as a therapeutic strategy for miR-193b-3p-mediated muscle regeneration.
Molecular therapy. Nucleic acids · 3 Sept 2026 · Journal Article
Small extracellular vesicles carrying miR-193b-3p promote muscle regeneration by targeting AP2M1, with a significant impact observed in vitro and in vivo.
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https://jclub.com.au/a/42823972
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Bacterial Stimulation Remodels Macrophage Extracellular Vesicle Lipids and Reveals iNOS as an Inflammatory Cargo
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.11.693607
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VDisk: A Microfluidic Cartridge for Automated and Reproducible Label-Free Isolation of Extracellular Vesicles from Plasma
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.04.674190
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Epigenetic Reprogramming Alters Intestinal Stem Cell Fate in Pouchitis
bioRxiv · 24 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.19.644201
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Arc mediates intercellular synaptic plasticity via IRSp53-dependent extracellular vesicle biogenesis
bioRxiv · 17 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.01.30.578027
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pH-Sensitive Amino Lipid-Driven Pore Formation Enables Endosomal Escape of Lipid Nanoparticles.
Nature Communications · 13 Aug 2026 · Journal Article
pH-sensitive amino lipid-driven fusion via stalk-pore mechanism enhances endosomal escape of lipid nanoparticles, improving nucleic acid delivery efficiency.
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Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37 to promote tumor progression.
Cell Reports · 12 Aug 2026 · Journal Article
Melanoma exosomal hsa-miR-221-5p suppresses keratinocyte LL-37, promoting tumor progression by impairing immune defenses and enhancing invasion.
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https://jclub.com.au/a/42593966
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Surface functionalization of small extracellular vesicles derived from Caco-2 and HEK293T cells in the neutralization of Shiga toxin 1 subunit B
bioRxiv · 10 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.23.720326
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Streptomyces Extracellular Vesicles Promote Plant Defence Responses Through Direct Pathogen Inhibition and Immune Activation.
Plant, Cell & Environment · 7 Aug 2026 · Journal Article
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https://jclub.com.au/a/42563703
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Lung-Selective Immune Reprogramming via In Situ Red Blood Cell Hitchhiking Nanoparticles
bioRxiv · 6 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.27.708550
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Pathogenic Bacteria Remotely Remodel Host Membrane Mechanics via Extracellular Vesicles to subvert Phagosome Maturation and Promote infection
bioRxiv · 5 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.17.694930
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