Long-Term Neurovascular Dysfunction and Altered Placenta-Derived EV miRNA Profiles in a Rat Model with Preeclamptic Features

At 2 months after delivery, transgenic rat model with preeclamptic features (TGA-PE) shows reduced middle cerebral artery elastin and impaired associative learning with reduced progressive-ratio motivation.

• Why it matters: Preeclampsia is linked to long-term cardiovascular, cerebrovascular, and cognitive risk, yet the neurovascular mechanisms and biomarkers driving persistent dysfunction remain unclear.
• What they did: The study used transcranial Doppler and photoacoustic imaging to assess MCA hemodynamics and cerebral oxygenation, plus touchscreen cognitive testing and histology; placenta-derived extracellular-vesicle miRNA sequencing identified 29 differentially expressed miRNAs.
• The result: miR-363-3p is reduced in non-placental EVs and plasma at 2M, and inhibiting miR-363-3p in HBEC-5i upregulated NOX4, p21, and β-galactosidase, suggesting a protective role in endothelial oxidative stress and senescence.

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