A Dual-Species Plant-derived Extracellular Vesicle and Growth Factors Formulation for Hair and Scalp Care: A Randomized, Placebo-controlled Study

In a 56-day randomized placebo-controlled trial in 60 healthy adults, the combined rIGF-1, rFGF-7, Centella asiatica, and ginger EV formulation (Group E) reduced excess sebum by 67% by Day 56.

• Why it matters: Scalp dysregulation and hair shedding are common cosmetic concerns, creating demand for non-pharmaceutical topical options with measurable effects over time.
• What they did: Adults were assigned to five topical groups (placebo, base, base plus rIGF-1/rFGF-7, base plus Centella asiatica and ginger EVs, or base plus all components) and assessed at Days 14, 28, 42, and 56 versus baseline.
• The result: Group E showed a time-dependent, highly significant sebum reduction and also accelerated hair growth kinetics, increasing cumulative length to nearly 3.9 cm by Day 56, with weekly growth velocity rising to 1.4 cm/week.

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