Molecular phenotypes and spatial archetypes reveal distinct CAF identities linked to tissue context, advancing precision targeting in cancer therapy.
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Cancer Cells and Metastasis
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MYC drives tissue-specific and systemic metabolic reprogramming in tumors, creating context-dependent vulnerabilities that can be targeted for therapy.
Molecular and functional organization of nutrient absorption varies regionally along the small intestine, with distinct gene expression profiles across axes.
Blood-based biomarkers show promise for early detection and management of liver cancer but require further validation in clinical settings.
Lineage transformation to squamous identity enables KRAS inhibitor resistance in mouse lung adenocarcinoma models, independent of KRAS/MAPK pathway reactivation.
Hepatocytes support pancreatic cancer liver metastasis by producing serine through a CXCL5-CXCR2-driven pathway, promoting tumor growth in the liver.
- Open access
Liver microenvironment promotes secondary breast cancer spread by enhancing metastasis, while lung microenvironment restricts this process, favoring local growth.
- Open access
Piezo2-expressing neurons and glial cells initiate early macrophage activation, driving inflammation in postoperative ileus in mice.
Tahoe-100M maps 100 million single-cell transcriptomes across 50 cancer cell lines under 1,100 drug conditions, revealing detailed drug-induced molecular phenotypes.
- 1 opens in JClub
- Open access
Conserved chemoresistance across cancers is driven by a proliferative, MYC-regulated tumor state involving SRM, with over 70% of resistant cells showing elevated cell cycle activity.
- Open access
Human-derived cortical organoids transplanted into mouse brains form extensive, integrated xenocortical circuits with diverse human cell types, including layer 5 projection neurons.
- Open access
- 1 cites
KLF4 drives a KRT13+ hillock-like cell state in lung squamous cell carcinoma, linked to therapy resistance and tumor heterogeneity.
NDST2-driven N-glycosylation of EGFR at four conserved sites promotes lenvatinib resistance in hepatocellular carcinoma, with NDST2 upregulation correlating with resistance.
Circulating tumor DNA-guided therapy in high-risk colon cancer achieved a 2-year relapse-free rate of 88% in ctDNA-negative patients, but did not meet the predefined threshold.
- Open access
ProteinTalks, a virtual cell model trained on over 38 million proteomic measurements, accurately predicts drug responses and resistance in breast cancer models.
- 1 cites
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