bioRxivJClub
Spatiotemporal dynamics of tumor microenvironment remodelling
bioRxiv · · Preprint · Open access
Lisek, Pentimalli + 24 more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Temporal ordering of spatial transcriptomes from 100+ ducts in triple-negative breast cancer mice maps spatiotemporal tumor microenvironment remodeling and identifies early stromal programs and signaling axes.
- Why it matters: Early TME remodeling is critical for interceptive therapies, but clinical samples usually capture only isolated, late-stage snapshots of tumorigenesis.
- What they did: The study used mice with multifocal, asynchronous tumors spanning a continuous luminal-to-basal transdifferentiation trajectory, then ordered spatial transcriptomes along that path.
- The result: The stromal remodeling dynamics are conserved across genetically heterogeneous patient-derived xenograft models and treatment-naive human TNBC cohorts, supporting translational relevance and revealing targetable early mechanisms.
The findingWhy it mattersWhat they didThe result
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- Open access
- 3 cites