Nature-derived exosome-like nanoparticles (NELNs) are promising RNA delivery vehicles, but clinical translation is hindered by the lack of a consensus definition and standardized manufacturing workflows.
Metabolic dysfunction in type 2 diabetes is linked to altered plasma extracellular vesicle miRNA signaling to prostate cancer cells, with metformin reducing EV-driven tumor progression activity.
A meta-analysis of 515 human plasma extracellular vesicle proteomes defines a reproducible core proteome, governed by surface-charge-driven mass-action and linked to thrombin-induced platelet degranulation.