interferon and immune responses
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Latest in interferon and immune responses
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IL-1α drives expansion of SLC2A1highSPP1highIFNlow myeloid cells, promoting immune escape and malignant transformation in pre-cancerous head and neck lesions.
NLRP3 inflammasome integrates innate immune signaling and cell death pathways, coordinating inflammatory responses and pyroptosis during infections and inflammation.
- Open access
Genetic variation in HLA, IGKV, and HHEX loci significantly influences COVID-19 vaccine-induced neutralizing antibody responses and protection, with HLA linked to reduced breakthrough infections.
- Open access
Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating chaperone-mediated autophagy and promoting tumor growth and viral persistence.
EBV-encoded v-snoRNA1 guides 2'-O-methylation of human rRNAs at conserved sites, reducing translation and slowing cell proliferation to regulate viral latency and lytic switch.
- Open access
TRIM62 enhances influenza A virus entry by modulating WASH-dependent endosomal trafficking, promoting viral internalization through retromer regulation.
- Open access
Viral Interference Programmable Repeat (VIPR) systems reveal a noncontiguous RNA code for DNA recognition, shedding light on the origin of CRISPR-Cas immunity.
- 1 cites
AP2-HS regulates environmental induction of sexual conversion in Plasmodium falciparum, involving a feedback loop that controls gdv1 expression and gametocyte formation.
Ancient viral interactions likely shaped the development of modern class 1 CRISPR bacterial immune systems.
High IGF2BP2 expression drives tumor growth and immune evasion in PTCL, with overexpression observed in 3 independent cohorts and 196 patient samples.
- Open access
PTI activates alternative splicing of potato NLR Rpi-vnt1.1 mRNA, removing a repressive prodomain and enabling immune response, revealing a new immune regulation layer.
Inhibiting PPM1D disrupts mitochondrial integrity, activates cGAS-STING signaling, and enhances antitumor immunity in hepatocellular carcinoma models.
Endogenous viral elements in Bombyx mori show diverse roles, with BmToEVE reducing virus susceptibility and BmChuEVE3 increasing it, impacting development and immunity.
- Open access
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- Lancet149
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Moving areas, week to 3 Oct 2026
- Single-cell and spatial transcriptomics10
- Artificial Intelligence in Healthcare and Education8
- CAR-T cell therapy research7
- Neuroinflammation and Neurodegeneration Mechanisms6
- Lung Cancer Treatments and Mutations5
- Diabetes Treatment and Management4
- Pancreatic and Hepatic Oncology Research4
- Photosynthetic Processes and Mechanisms4
- Genomics and Chromatin Dynamics4
- Gut microbiota and health4