ER-phagy orchestrates virus-host interactions across kingdoms.

ER-phagy (reticulophagy) is a conserved antiviral defense across kingdoms that restricts infection by targeting viral replication organelles and degrading viral components.

• Why it matters: ER-phagy is linked to virus–host outcomes, but the dynamic interplay—how it restricts infection and how viruses counteract or exploit it—needs clearer framing for intervention.
• What they did: The work synthesizes evidence that ER-phagy targets viral replication organelles and viral components, while viruses can counteract or exploit the pathway.
• The result: The interplay is proposed to shape infection outcomes and positions ER-phagy as a promising target for antiviral intervention.

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