Research area · week to 3 Oct 2026

Endoplasmic Reticulum Stress and Disease

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SARM1 executes neuronal parthanatos and promotes excitotoxic cell death.
Neuron · 19 Aug 2026 · Review
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p97-mediated proteostasis is a checkpoint for late-stage thymocyte positive selection.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
p97 is essential for late-stage thymocyte positive selection, with its loss causing a severe blockade in CD8+ lineage commitment and thymocyte development.
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https://jclub.com.au/a/42706435
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Immune safeguarding as a conserved principle of antiviral defence.
Nature Reviews Microbiology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42469434
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Oncogenic viral infection triggers LAMP2A SUMOylation and chaperone-mediated autophagy to promote tumorigenesis.
Nature Microbiology · 29 Sept 2026 · Journal Article
Oncogenic viruses induce LAMP2A SUMOylation via TRIM32, activating chaperone-mediated autophagy and promoting tumor growth and viral persistence.
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https://jclub.com.au/a/42811103
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Distinct modes of folding assistance in cells by protein- and RNA-based chaperones
bioRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.15.718697
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Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753071
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Replication stress in cancer: origins, consequences and therapeutic opportunities.
Nature Reviews Cancer · 22 Sept 2026 · Review
Replication stress drives tumor evolution and creates therapeutic vulnerabilities, with over 100 clinical trials exploring ATR, CHK1, and WEE1 inhibitors.
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https://jclub.com.au/a/42773173
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Dynamic allocation of DnaK couples proteostasis demand to chaperone availability
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.01.735817
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Beyond ER-Golgi trafficking: unconventional protein secretion as a new design frontier for synthetic secretion switches in mammalian cells.
Communications Biology · 19 Sept 2026 · Review
Unconventional protein secretion offers new design principles to enhance rapid control of extracellular protein release in mammalian cells.
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https://jclub.com.au/a/42763312
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In vivo imaging uncovers an abundant but rarely active pool of plant ARP2/3 and its link to exocytosis and endocytosis
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.10.737699
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A viral protein promotes host L-asparaginase activity and weakens the asparagine-induced resistance pathway for the benefit of virus infection.
Journal of Experimental Botany · 16 Sept 2026 · Journal Article
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https://jclub.com.au/a/42316991
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The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.04.20.537611
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How SCREW finds its NUT.
Nature Plants · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42754652
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The ER-Golgi intermediate compartment: a central hub integrating membrane trafficking and stress responses.
EMBO Reports · 1 Sept 2026 · Review
The ER-Golgi intermediate compartment acts as a central stress-responsive hub, integrating membrane trafficking and immune responses, with over 50 key functions identified.
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https://jclub.com.au/a/42632860
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Author Correction: In situ cryo-ET defines the ultrastructure of ER exit sites in human cells.
Nature Cell Biology · 1 Sept 2026 · Published Erratum
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CaSAP8-CaDSK2a Negative Feedback Loop Modulates Pepper Thermotolerance by Integrating Transcriptional Repression and Protein Degradation.
Plant, Cell & Environment · 1 Sept 2026 · Journal Article
CaSAP8 and CaDSK2a form a negative feedback loop that dynamically regulates thermotolerance in pepper, with CaSAP8 enhancing and CaDSK2a attenuating heat stress responses.
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https://jclub.com.au/a/42157437
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Genome-wide identification of HSF family in tree peony reveals the function of PsHSFA3 in response to thermal stress.
Plant Physiology and Biochemistry · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42612470
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Atg23 prevents aberrant fusion of Atg9 vesicles during delivery to autophagosome formation sites.
EMBO Journal · 1 Sept 2026 · Journal Article
Atg23 prevents inappropriate fusion of Atg9 vesicles during autophagosome formation in yeast, ensuring proper membrane delivery for autophagy.
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https://jclub.com.au/a/42477132
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FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators.
EMBO Journal · 1 Sept 2026 · Journal Article
FAF1 and FAF2 significantly boost p97-UFD1-NPL4 complex activity, increasing substrate unfolding efficiency by engaging key cofactors and conserved activation motifs.
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https://jclub.com.au/a/42603836
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Local translation of endosome-associated lc3b mRNA in axons contributes to endosomal clearance.
EMBO Reports · 1 Sept 2026 · Journal Article
Endosome-associated lc3b mRNA is locally translated in axons, facilitating endosomal clearance through autophagy, with over 50% of endosomes showing LC3B colocalization.
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https://jclub.com.au/a/42469500
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Autophagy modulation in cancer.
Nature Reviews Drug Discovery · 1 Sept 2026 · Review
Autophagy plays a complex, dual role in cancer, supporting tumor survival and immune responses, making it a challenging but promising therapeutic target.
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https://jclub.com.au/a/42151413
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Survey of the human proteostasis network: the ubiquitin-proteasome system
bioRxiv · 30 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.13.711689
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Novel compound heterozygous SIL1 variants associated with Marinesco-Sjögren syndrome in a Chinese family.
Frontiers in Genetics · 28 Aug 2026 · Journal Article
Novel compound heterozygous SIL1 variants linked to Marinesco-Sjögren syndrome in a Chinese girl impair SIL1-BiP interaction and reduce protein levels.
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https://jclub.com.au/a/42724971
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Functional analysis of TTN uORFs reveals context-dependent translational regulation.
Molecular therapy. Nucleic acids · 28 Aug 2026 · Journal Article
Disruption of TTN uORFs does not increase titin expression in human cardiomyocytes, revealing context-dependent regulation of TTN translation.
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https://jclub.com.au/a/42761362
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Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Diverse Protein Abundance Regulation during Endoplasmic Reticulum Stress
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.23.666381
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Distinct roles for TANGO1S domains in maintaining ER-Golgi architecture
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.28.721365
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Cell-type-specific APOE4 cascade across the Alzheimer's disease continuum.
Neuron · 19 Aug 2026 · Review
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https://jclub.com.au/a/42140183
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SARM1 executes neuronal parthanatos and promotes excitotoxic cell death.
Neuron · 19 Aug 2026 · Review
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OsGSK2 Phosphorylates Heat Shock Factor OsHSF7 to Regulate Rice Thermotolerance.
Plant, Cell & Environment · 12 Aug 2026 · Journal Article
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https://jclub.com.au/a/42584075
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CPAP/CENPJ is essential for the stability and function of ESCRT-pathway associated AAA+ ATPase VPS4B
bioRxiv · 12 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.728888
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E3 ubiquitin ligase HUWE1 mediates K6-linked polyubiquitylation and stabilization of Nrf2 to restrict hepatitis B virus replication
bioRxiv · 8 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.20.719611
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