Cell RepJClub
Neuroprotectant development from small molecule inhibitors of CHOP/ATF4 expression.
Cell Reports · · Journal Article · Open access
Li, Yan + more
Abstract ↗AI summary
The abstract is read at the publisher; the summary is JClub's.
Two analogs identified from high-throughput screening inhibit ER stress–induced CHOP expression and activate ATF4, and they protect retinal ganglion cells in optic neuropathy models.
- Why it matters: Glaucoma involves ER stress linked to optic nerve injury, and targeting the ATF4–CHOP branch is needed to develop neuroprotective therapies.
- What they did: The study screened for small molecules that inhibit CHOP expression, then performed structure–activity relationship analysis on one hit to generate two potent analogs affecting CHOP and ATF4.
- The result: In two optic neuropathy models, the analogs increased survival of retinal ganglion cell somata and axons and preserved visual function, supporting further drug development.
The findingWhy it mattersWhat they didThe result
- Open access