Genomic regulatory landscape underlying the antiviral response of Atlantic salmon.

Poly I:C stimulation in farmed Atlantic salmon (Salmo salar) activates 197 interferon-stimulated genes whose regulatory elements gain chromatin accessibility and H3K27ac alongside increased expression.

• Why it matters: Interferon-driven antiviral programs are conserved across jawed vertebrates, but the regulatory logic and how it varies after salmonid whole-genome duplication remain unclear.
• What they did: Atlantic salmon were systemically stimulated with poly I:C, then mRNA-seq plus ATAC-seq and ChIP-seq for H3K27ac and H3K27me3 were used to map gene-expression changes to regulatory chromatin features.
• The result: The 197 ISGs include 54 conserved genes across rainbow trout, zebrafish, and humans, and paralog-specific ISRE motif enrichment in retained duplicates suggests WGD-shaped interferon regulation.

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