Cellular Mechanics and Interactions
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Latest in Cellular Mechanics and Interactions
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Bidirectional actomyosin redistribution drives epithelial invagination, with 2 distinct phases involving apical constriction and lateral contractility in ascidian siphon tube development.
- Open access
Profilin enhances lamellipodium protrusion by regulating the balance between capping protein and VASP, crucial for actin network formation in cell migration.
- Open access
Confinement force microscopy reveals two-phase cellular responses to dynamic spatial confinement, with a 2-fold increase in traction forces during active stress buildup.
- Open access
Stochastic heterogeneity and dynamic instability in sarcomeres enable robust cardiomyocyte contraction despite mechanical constraints, with 85 kPa stiffness revealing significant heterogeneity.
- Open access
- 1 cites
Microbial adhesion activates Piezo1 to initiate innate immunity, triggering neutrophil recruitment before pattern recognition receptor engagement.
- Open access
βII-spectrin forms a distinctive gaps-and-patches pattern in human motor neuron axons, revealing a patterned assembly of the actin/spectrin membrane skeleton.
- Open access
Cell-body curvature in Vibrio cholerae reduces stall frequency by 86%, boosting chemotaxis in mucus-like hydrogels and enhancing pathogenic movement.
- Open access
Tissue flows guide immune cell polarization and migration, with local ectodermal flows directing embryonic myeloid cell dispersion in Xenopus embryos.
- Open access
Inorganic phosphate increases Arp2/3-induced actin branch stability by 30-fold compared to the ADP state, highlighting Pi as a key regulator of actin network integrity.
- Open access
Cell state transitions during tissue morphogenesis are dynamically regulated by gene expression, chromatin, and biophysical signals, enabling precise tissue formation and function.
- Open access
Thymosin alpha-1 restores chemotherapy-induced antitumor immunity by protecting microRNA ligands of TLR7 in dendritic cells, enhancing tumor control in mice.
kpiCells, a biomimetic platform, can measure piconewton-scale forces and replicate cellular states, advancing the study of immune cell mechanoregulation with high functional complexity.
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