A predictive mechanochemical modeling framework for the deformation and remodeling of the nuclear lamina

Nuclear lamina rupture likelihood is strongly predicted by substrate nanotopography and lamin abundance, with highest NE tension on nanopillars spaced by 5–7 microns.

• Why it matters: Mechanochemical cues from microenvironments can deform and rupture the nucleus, but predicting how these signals reshape nucleocytoplasmic transport and lamina remodeling remains unresolved.
• What they did: A finite element framework simulated NE compression from the perinuclear actin cap on nanopillar arrays, coupling nonlinear NE-lamin mechanics to biochemical lamin remodeling and nucleocytoplasmic transport, then tested YAP/TAZ and rupture experimentally.
• The result: The model matched nuclear morphology measurements, linked maximal NE stretch to nanopillar contacts, showed increased flattening promotes YAP/TAZ nuclear localization via NPC dilation, and predicted rupture force load validated in lamin-depleted U2OS cells.

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