Research area · week to 3 Oct 2026

Pain Mechanisms and Treatments

Moving in bioRxiv, Cell Reports, Frontiers in Genetics, Gut, medRxiv, Neuron.

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Latest in Pain Mechanisms and Treatments

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IgG4 sensitizes human dorsal root ganglia neurons and patient-derived IgG induces FcγR-dependent pain hypersensitivity in mice
medRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.12.24317004
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E-Selectin Orchestrates IL-1B-Dependent Neuroinflammation via NLRP3 in Vincristine-Induced Neuropathy
bioRxiv · 29 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.10.710929
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Concordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.753017
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Evaluating home-cage-activity metrics for detecting postprocedural pain in a plantar incision mouse model
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753854
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Forsythoside B attenuates neuropathic pain by suppressing USP7/HIF-1α-mediated microglial glycolytic reprogramming
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752649
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The left PBN to aCM pathway mediates pain-related aversion in male mice.
Cell Reports · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42752087
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Modulation of human dorsal root ganglion neuron excitability by Nav1.7 inhibition
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.26.714428
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Precision Functional Mapping of Imagined and Experienced Pain
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.06.668906
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Increased activity in the somatosensory and insular cortex during the transition from acute to chronic neuropathic pain
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.25.747057
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Cocaine-Enhanced Enkephalin Gates Plasticity of Distinct Striatal Synapses and Facilitates Cue-Induced Cocaine-Seeking During Abstinence
bioRxiv · 1 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.11.711212
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Interaction of attention and localization of pain maxima shift the balance between lateral inhibition and spatial facilitation in nociceptive processing
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.14.711815
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Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.06.19.599732
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Top-down control of the descending pain modulatory system drives multimodal placebo analgesia.
Neuron · 19 Aug 2026 · Journal Article
Cortical and brainstem circuits, especially the ventrolateral periaqueductal gray, causally mediate multimodal placebo analgesia in mice, with lasting effects after injury.
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https://jclub.com.au/a/41997148
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Nucleus raphe magnus serotonin neurons bidirectionally control spinal mechanical pain transmission
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.09.647804
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DRG meningeal tertiary lymphoid structures are regulated by B cells as a pronociceptive locus after peripheral nerve injury
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.09.743585
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SEPTIN9 R106W in a Chinese family with hereditary neuralgic amyotrophy: phenotypic heterogeneity and rehabilitation in a pediatric case.
Frontiers in Genetics · 12 Aug 2026 · Journal Article
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https://jclub.com.au/a/42644177
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Neuropilin-1 in CGRP Afferents Is Required for VEGFA-Driven Pain and Baseline Nociceptive Sensitivity
bioRxiv · 12 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.06.723195
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Low-frequency repetitive transcranial magnetic stimulation attenuates visceral pain in IBS with diarrhoea via inhibition of the medial prefrontal cortex.
Gut · 6 Aug 2026 · Journal Article
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https://jclub.com.au/a/41629148
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