The abstract is read at the publisher; the summary is JClub's.
In a multicenter RCT in painful diabetic neuropathy, 10-kHz spinal cord stimulation plus CMM produced ≥50% lower-limb pain relief in 27/34 trialed participants versus 2/50 with CMM alone (P < 0.001).
- Why it matters: Painful diabetic neuropathy leaves patients with persistent pain and sensory loss, and prior work needed confirmation that high-frequency 10-kHz SCS improves sensory function with objective biomarkers.
- What they did: Participants were randomized 1:1 to CMM alone or 10-kHz SCS plus CMM, with allocation-blinded mTCNS and IENFD; primary outcomes used ≥50% lower-limb pain relief and sensory improvement used ≥3-point mTCNS reduction.
- The result: At 6 months, sensory improvement occurred in 16/29 (55.2%) versus 12/48 (25.0%) (P = 0.01), and mean lower-calf IENFD change was 0.58 fibers/mm versus -0.07 (P = 0.03), with 8 of 10 hierarchical secondary endpoints met.
The findingWhy it mattersWhat they didThe result
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