Diabetes Care

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Teplizumab’s 2026 U.S. approval for children and adolescents aged 8–17 with new-onset stage 3 type 1 diabetes reshapes the first weeks after diagnosis.

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Hypoglycemic events in adults with type 1 diabetes occurring within 0–1 h before smartphone cognitive testing are linked to slower reaction time and poorer DSM and GCPT performance.

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rs2129019 in SLC2A2 (GLUT2) is linked to a 38% increased risk of metabolic failure per A allele on glimepiride in African/African American participants.

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Lower fecal elastase-1 during the first 6 months of life predicts later multiple islet autoantibodies or type 1 diabetes in ENDIA children, with β-coefficients down to -0.61 at birth.

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A best practice advisory in the electronic health record increased DSMES referral rates for adults with type 2 diabetes in central North Carolina to 13.7% at 18 months.

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PMOS affected 17.1% (95% CI 15.9–18.3) of 3,645 pregnant women in an international multicenter cohort, and was linked to higher odds of early GDM.

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In adults with type 1 diabetes, older age and chronic kidney disease show longitudinal improvement in time in range over 3 years without worsening hypoglycemia, unlike severe β-cell failure.

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In a multicenter RCT in painful diabetic neuropathy, 10-kHz spinal cord stimulation plus CMM produced ≥50% lower-limb pain relief in 27/34 trialed participants versus 2/50 with CMM alone (P < 0.001).

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Below-knee amputation in 25,176 people with diabetes in England shows 23.5% all-cause mortality at 1 year and 82.3% at 10 years, with no improvement since 2012.

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MetALD, a steatotic liver disease subcategory defined by metabolic dysfunction plus alcohol use, is linked to higher all-cause, cancer-related, and liver-related mortality than MASLD in the U.S. context.

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In a retrospective cohort of 954 pregnant individuals with type 2 diabetes, weight gain <5 kg is linked to lower risk of large-for-gestational-age birth weight (aOR 0.42, 95% CI 0.29–0.59).

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In 102 men with overweight or obesity and hyperuricemia, 12-week calorie-restricted CRD, DASH, and LPBD diets produced similar serum urate reductions (P = 0.48).

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Initiating oxycodone in adults with type 2 diabetes on GLP-1 receptor agonists is linked to higher 30-day motility-related GI event risk (0.51%) than hydrocodone (0.35%) or tramadol (0.33%).

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From 2016–2022 in U.S. delivery hospitalizations, nontransfusion severe maternal morbidity rose from 72.0 to 93.0 per 10,000 deliveries, alongside increasing diabetes prevalence.

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Weekly well-day capillary ketone testing is the lowest frequency that maintained similar 1-month DKA prediction accuracy in type 1 diabetes, using EASE-2/EASE-3 data (AUC 0.719 vs 0.711).