The abstract is read at the publisher; the summary is JClub's.
Lower fecal elastase-1 during the first 6 months of life predicts later multiple islet autoantibodies or type 1 diabetes in ENDIA children, with β-coefficients down to -0.61 at birth.
- Why it matters: Exocrine pancreatic function may be involved early in type 1 diabetes, but noninvasive longitudinal biomarkers that track this timing are not well defined.
- What they did: In the ENDIA cohort, FE-1 and serum immunoreactive trypsin were measured prospectively from birth in 301 at-risk children, using nested case-control comparisons and adjusted linear mixed models.
- The result: FE-1 showed lower early trajectories (β at birth -0.61, P=0.006; β at 3 months -0.39, P=0.010) and IRT was lower at 12 and 18 months before diagnosis, implying early exocrine changes can be detected.
The findingWhy it mattersWhat they didThe result
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