Research area · week to 3 Oct 2026

Diabetes and associated disorders

Moving in bioRxiv, Cellular & molecular immunology, eLife, The American Journal of Human Genetics, Cell Metabolism, Environmental pollution, Environmental research, Journal of hepatology.

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Metabolic switch: lymphocytes and the onset of T-cell-mediated autoimmunity.
Cellular & molecular immunology · 1 Oct 2026 · Review
Metabolic reprogramming in lymphocytes, including increased glycolysis and mitochondrial dysfunction, drives T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
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https://jclub.com.au/a/42634089
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The ISChip: A high-throughput qPCR array for absolute quantification of insertion sequences across the One Health continuum.
Environmental pollution · 1 Oct 2026 · Journal Article
ISChip enables absolute quantification of 183 insertion sequences across diverse environmental samples with high sensitivity, revealing key hotspots in the One Health continuum.
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https://jclub.com.au/a/42349820
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MARCH2/3 target FcγRI for K27-linked polyubiquitination and degradation to restrict the inflammatory response.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and degradation, limiting inflammatory responses and disease severity.
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https://jclub.com.au/a/42595851
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γδ T cell receptor dependencies define a unique immunosurveillance modality.
Nature · 30 Sept 2026 · Journal Article
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https://jclub.com.au/a/42816614
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Glutamine metabolism as a rheostat of CD4(+) T cell pathogenic function in metabolic dysfunction-associated steatotic liver disease.
Cell Metabolism · 18 Sept 2026 · Journal Article
Hepatic glutamine metabolism critically regulates pathogenic CD4(+) T cell inflammation, with Gln depletion linked to increased liver damage in MASLD.
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https://jclub.com.au/a/42759512
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Long-term environmental exposures and Diabetes Mellitus type 2 incidence in over 240,000 Dutch adults.
Environmental research · 15 Sept 2026 · Journal Article
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https://jclub.com.au/a/42492750
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The C3-C3aR axis modulates trained immunity in alveolar macrophages.
eLife · 10 Sept 2026 · Journal Article
C3-C3aR signaling enhances trained immunity in alveolar macrophages, with C3 deficiency impairing cytokine production and metabolic activity in mice.
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https://jclub.com.au/a/42720115
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Retraction notice to "Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population" [J Hepatol 58 (2013) 271-277].
Journal of hepatology · 1 Sept 2026 · Retraction Notice
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Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses.
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.24.619799
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Donor-derived CD8+CD122+ Tregs generated in mixed donor chimeric NOD mice suppress autoreactive T cells
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.20.712252
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Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females.
eLife · 20 Aug 2026 · Journal Article
Female thymocytes show a 2.4-fold higher prevalence of TCRs specific to autoimmunity-related self-antigens than males, indicating a sex-biased bias in thymic selection.
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https://jclub.com.au/a/42623268
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Long-Term Survival of Hypoimmune Allogeneic Islets without Immunosuppression.
New England Journal of Medicine · 20 Aug 2026 · Letter
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https://jclub.com.au/a/42430558
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β-Hydroxybutyrate precursor 1,3-butanediol modulates enteric pathogen susceptibility and Th17 responses via commensal bacteria.
mSystems · 18 Aug 2026 · Journal Article
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https://jclub.com.au/a/42461015
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MAFB is essential for the maintenance of adult human α-cell identity and glucagon secretion
bioRxiv · 18 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.08.08.743687
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Overlapping Xq13.3 duplications define an X-linked hypotrichosis simplex and implicate TAB3 dosage sensitivity.
The American Journal of Human Genetics · 6 Aug 2026 · Journal Article
Overlapping Xq13.3 duplications increase TAB3 dosage, causing X-linked hypotrichosis simplex with a 3.4 Mb critical region.
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https://jclub.com.au/a/42425085
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Bi-allelic variants in the non-protein-coding minor spliceosome components RNU6ATAC and RNU4ATAC cause syndromic monogenic autoimmune diabetes.
The American Journal of Human Genetics · 6 Aug 2026 · Published Erratum
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